Synaptic activity-induced changes in the concentrationof intracellular calcium control many processes in neuronsincluding gene expression. Calcium signals propagatingtowards the cell soma and the nucleus are key mediatorsof synapse-to-nucleus communication. Nuclear calciumcontrols CREB/CBP-dependent transcription and regulatesgenomic programs critical for neuronal survival, plasticity,and memory

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Systemneurobiologie, Verhaltensneurobiologie

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